Divergency of leptin response in intestinal inflammation
نویسندگان
چکیده
منابع مشابه
INTESTINE INFLAMMATION Leptin receptor expression on T lymphocytes modulates chronic intestinal inflammation in mice
Background: Leptin regulates appetite through the long isoform of its receptor in the hypothalamus. Although leptin regulates immune responses, it is still unknown whether a direct effect of leptin on lymphocytes is required. Aims: To clarify whether expression of leptin receptors on T lymphocytes modulates intestinal inflammation in mice. Methods: The model of colitis induced by transfer of CD...
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Leptin-deficient ob/ob mice are resistant to dextran sulfate sodium (DSS)-induced colitis and Concanavalin A (Con A)-induced hepatitis. However, the signal transduction pathways involved have not been identified. The present study investigated the effect of leptin-induced STAT3 signaling in the DSS and Con A models. Mice carrying a leptin receptor (LEPR) gene mutant for Y1138 (s/s mice), with a...
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BACKGROUND Although leptin, an adipocyte derived hormone which regulates food intake and energy balance, is released after injections of tumour necrosis factor (TNF) and interleukin 1, plasma concentrations have not been characterised in chronic inflammation. Leptin may contribute to the anorexia and body weight loss associated particularly with the acute stages of inflammatory bowel disease. ...
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The adipocyte hormone leptin activates signal transducer and activator of transcription 3 (STAT3) in the hypothalamus, mediating increased satiety and increased energy expenditure. To date, leptin-mediated activation of the STAT pathway in vivo has not been established in tissues other than hypothalamus. We now describe leptin receptor expression and in vivo signaling in discrete regions of the...
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ON OCTOBER 30th, 2002, the World Health Report by the World Health Organization was launched subtitled Reducing risks, promoting healthy life. Many of the health risks discussed in this report concern food consumption—either too little, in the case of the poor, or too much, in the case of the better off. Two of the most striking findings in this report are to be found almost side by side. One i...
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ژورنال
عنوان ژورنال: Nutrition Clinique et Métabolisme
سال: 1999
ISSN: 0985-0562
DOI: 10.1016/s0985-0562(99)80042-9